Progress on Preparation of pH/Temperature-Sensitive Intelligent Hydrogels and Applications in Target Transport and Controlled Release of Drugs

Hydrogels with three-dimensional network structure, hydrophilic, and insoluble in water which are ideal carrier materials for intelligent drug delivery systems. Intelligent hydrogel has become a research frontier hotspot because of its intelligence, high efficiency, safety, convenience controlled prolonged release. It broad application prospect the medicine biomedicine fields can lead into new era “precise treatment.” Based on latest progress, main preparation methods development system briefly introduced. The most promising three hydrogels human physiological environment, namely, pH responsiveness, temperature pH/temperature dual emphatically reviewed. Their release mechanisms, targeting transport, controlled-prolonged also discussed. In addition, some suggestions problems future were given.